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In vitro - to-in vivo extrapolation (IVIVE) can be coupled with PBPK modeling as a way to predict the in vivo pharmacokinetic characteristics of a new drug based on in vitro studies

doi:10.1021/tx300395w pmid:23268549 Lang-Rollin I, Rideout HJ, Noticewala M, Stefanis L (2003) Mechanisms of caspase-independent neuronal death: energy depletion and free radical generation

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Individuals who have traveled from high-risk countries or areas with confirmed nCOVID-19 cases and members of a family who are suffering from nCOVID-19 and not staying at home care or not maintaining isolation precautions are regarded as high-risk exposures