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For instance, OH radicals destroy the deoxyribose sugar backbone together with the nitrogenous base

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499 Sareptas SRP-5051, an ASO conjugated with a targeting peptide, has shown higher levels of dystrophin expression and exon skipping rates than eteplirsen

There is also a basic characterization step that would help before any of that: independent analytical confirmation of what is actually in research vials peptide purity, the true copper-to-peptide ratio, and the absence of endotoxin and contaminants so that findings can be tied to a defined substance rather than to material of unknown composition