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doi: 10.3389/fimmu.2026.1793440 Received 22 January 2026 Revised 25 February 2026 Accepted 06 March 2026 Published 23 March 2026 Volume 17 - 2026 Edited by Baocun Zhang, Aarhus University, Denmark Reviewed by Yibo Ma, Second Affiliated Hospital of Dalian Medical University, China Daniela Poenaru, Carol Davila University of Medicine and Pharmacy, Romania Updates Copyright 2026 Chen, Gao, Luo, Wang, Niken, Xu, Ding and Guo

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Thank you to our sponsors AG1: Maui Nui: Helix Sleep: Mateina: Function: Timestamps 00:00:00 Michael Easter 00:02:14 Discomforts, Modern vs Ancient Life 00:07:35 Sponsors: Maui Nui & Helix Sleep 00:10:17 Modern Problems, Exercise, Trail vs Treadmill Running, Optic Flow, Hunting 00:20:01 Risk & Rewards, Intellectual vs Experiential Understanding 00:23:39 Modern Luxuries, First-World Problems, Gratitude, Tool: Volunteer 00:34:33 Rites of Passage, Tool: Challenge, Narrative & Purpose

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The bidirectional interaction between the sympathetic nervous system and immune mechanisms in the pathogenesis of hypertension