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Description

Posttranslational processing of BDNF Secretory proteins are posttranslationally processed by different enzymes such as endo- or exopeptidases or glycosyltransferases (reviewed in Thomas 2002)

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Functions FAD and FMN are cofactors for enzymes that are involved in redox reactions (chemical reactions in which electrons are transferred from one substance to another), including: Succinate dehydrogenase (TCA cycle) FAD is part of glutathione reductase (GR) in erythrocytes: NADPH binds to GR reduction of FAD to FADH - FADH - breaks disulfide bond in GSSG GSR can be reduced Vitamin B 2 deficiency [15] [16] Causes Malnutrition Restricted diet (e.g., vegan, lactose-free) Demand: pregnancy, lactation Clinical features Corneal vascularization Cheilitis, glossitis, stomatitis, pharyngitis Normocytic normochromic anemia Seborrheic dermatitis Diagnosis Erythrocyte glutathione reductase assay: identifies subtle deficiencies Erythrocyte glutathione reductase activity coefficient: the activity coefficient (AC) of glutathione reductase is measured in the presence and absence of FAD The 2 C's of Vitamin B2 deficiency: Corneal vascularization and Cheilitis

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