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Targeting specific subunits of NF-B could improve the efficacy of cancer treatments and overcome resistance to traditional therapies like radiotherapy and chemotherapy [145]

The disease has active periods

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In an experimental autoimmune encephalomyelitis (EAE) model, blocking BCAT1-mediated leucine catabolism using BCAT1 inhibitors or LhL treatment alleviated the severity of EAE by reducing HIF1 expression and IL-17 production in spinal cord mononuclear cells