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-Lapachone and its iodine derivatives cause cell cycle arrest at G(2)/M phase and reactive oxygen species-mediated apoptosis in human oral squamous cell carcinoma cells

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doi:10.1530/REP-19-0197 Khan MJ, Ullah A, Basit S

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Unknown Long-Term Safety Profile: A short plasma half-life of under 30 minutes in rats and dogs, alongside low bioavailability after intramuscular administration, raises critical questions about what occurs with higher, repeated, or long-term exposures in humans