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Essays Biochem 2010;47:6984

Motoyama, K

Oral dosing ranges discussed in research community use Phase Weeks 12 (start low) Daily dose 50 mg once daily Notes Morning dosing is the pattern most often reported

There is evidence of increased risk of persistent pulmonary hypertension of the newborn (PPHN), neonatal adaptation syndrome (jitteriness, respiratory distress, feeding trouble, persistent crying), and rare reports of congenital heart defectsthough absolute risk is still low

The therapeutic window of opportunity meaning treating earlier in the disease is also important to make sure the disease doesnt quickly worsen with more serious problems

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