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Constipation is associated with mild cognitive impairment in patients with de novo Parkinson's disease

When your cells literally lack the molecular shuttles required to produce basic energy, the profound fatigue you experience is not a lack of willpower, motivation, or fitnessit is a very real, measurable physiological deficit

M., Vasiliu, D., Eremia, N

the definition of this profile showed a good level of homogeneity (mean inter-item Spearman 0.25) [41] and has been extensively described previously as belonging to the immuno-metabolic depression (IMD) domain, based on previous findings on individual symptoms with immuno-metabolic dysregulation [2]

Mantzorou M, Mentzelou M, Vasios GK, et al

This suggests a case of parallel adaptation to dietary extremes through distinct, population-specific genetic changes: the ancestral allele, combined with the insertion, helps vegetarians better metabolize their diet, while the derived allele is best suited for marine diets ( The FADS2 insertion allele in South Asians is believed to be an adaptive response to plant-based diets that provides a metabolic advantage by ensuring sufficient AA and DHA synthesis from vegetarian food sources ( FADS alleles common in Inuit reduce levels of certain unsaturated fatty acids, which was likely beneficial in their ecology, where they consumed large amounts of seal, blubber, and fish oil daily