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The activation of microglia by -syn involves toll-like receptors (TLRs) and NF-B signalling, both of which transcriptionally upregulate p62 to facilitate the clearance of pathogenic -syn (Figure 2B) [109,250]

doi: 10.1038/s41366-018-0189-8 133 van der KolkBWKalafatiMAdriaensMvan GreevenbroekMMJVogelzangsNSarisWHMet al

Rodriguez-Lago, I

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Fluid retention is another known side effect associated with the use of thiazolidinediones (TZDs)

in patients receiving valproate, the initial dosage of lamotrigine must be reduced to 25 mg every other day