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In the innate immune response, the activation of Pattern Recognition Receptors (PRRs) on the cell membrane leads to long-term activation of double-stranded RNA-dependent protein kinase (PKR), resulting in the inactivation of the DNA repair kinase ATM (part of the PI3K protein kinase family) and the phosphorylation of p65 NF-B, thereby promoting IFN- synthesis ( IPK (115)

The present study investigates the relationship between the transcriptional regulator transcription factor AP-2 alpha(TFAP2A) and S100A2, both of which have been observed to show high expression in lung adenocarcinoma (LUAD) [60]

doi: 10.1186/s12885-022-09679-x 37 YuanLLiuJBaoLQuHXiangJSunP

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