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182 The senescence and exhaustion of HSCs are the core reasons for the decline in hematopoietic system function, involving multiple mechanisms such as telomere attrition, oxidative stress, inflammatory disorders and epigenetic disorders, which ultimately lead to anemia, immunodeficiency, and an increased risk of hematological diseases

Mancino G, Miro C, Di Cicco E, Dentice M

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doi: 10.1038/ni.1937 87 YaoYXuX-HJinL

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