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In preclinical toxicity studies, no lethal dose has been identified (meaning researchers could not find a dose high enough to cause death in animals), and few side effects have been reported in animal models

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PEFR: peak expiratory flow rate

Response: We appreciate and acknowledge these comments related to the implementation of the transfer of care modifiers proposal

All three measures showed significant improvement after 1 month on the diet, with significant differences between baseline severity categories