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The SCN, located above the optic nerve crossing, plays a pivotal role in regulating the timing of sleep and wakefulness [174]

Benfotiamine, a fat-soluble thiamine homolog, is a synthetic S-acyl derivative of thiamine that has been shown to block three major pathways of hyperglycemia-induced microvascular damage [110]

Maintaining an optimal level of glutathione appears to be important for supporting cognitive function, especially during aging.* The normal process of aging is associated with a decrease in glutathione activity, which can result in increased oxidative activity.* Less than optimum levels of glutathione are observed in individuals experiencing a decline in cognitive function.* Conversely, individuals living over 100 years tend to have higher glutathione activity.*

Light and electron microscopic analyses were further employed to evaluate the potential morphological changes after standard CPA loading and vitrification

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Addressing these gaps will be critical for validating FA scavenging as a viable therapeutic approach for diabetic encephalopathy