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ROS generated by the Fenton reaction tends to react with phospholipids (PL) to form hydroperoxy-phospholipids (PLOOH), which are the main elimination target of GPX4 (Wiktorowska-Owczarek et al., 2015)

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doi: 10.3390/bioengineering6040113 20 CleversH

Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritis

This distal ROS spread correlated with rapid trafficking of oxidized mitochondria toward distal regions of the cell (Supplementary Movie 3), but mitochondrial motility across the cell was rarely visualized ( ~ 13% of total photostimulations) in our experimental timescale

Just think about fluid pressure in a small container being pushed, pushed, pushed until the can or the container is ready to explode, and how multiple features, multiple variables could impinge on that and create that pressure