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Trontinemab, an anti-amyloid monoclonal antibody fused to a transferrin receptor-binding shuttle module designed to enhance receptor-mediated transcytosis, is currently being evaluated in Phase I/II clinical studies, with early data indicating substantially increased brain exposure compared with conventional antibodies (Grimm et al., 2023)

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These observations suggest the neuroprotective role of SIRT1 against the development and progression of PD

NMR chemical shift perturbation analysis The CSPs were calculated according to the following equation: where H and N indicate the chemical shift changes of the amide proton and nitrogen, respectively, using CcpNMR 2.5 49

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