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To address this, we chose primary hepatocytes cultured in a sandwich configuration as this is the preferred method for in vitro drug disposition and hepatotoxicity studies (44)

The results of another randomized trial in 39 patients with Alzheimers disease suggested that supplementation with fish oil concentrate (high in omega-3 fatty acids) with or without lipoic acid (600 mg/day) for one year could delay the progression in cognitive and functional impairments assessed by the Instrumental Activities of Daily Living (IADL) scoring system compared to placebo (104)

Although not directly tested with HTX, loading urolithins into milk exosomes enhanced their delivery to the brain, illustrating the potential of exosomes as biological delivery vehicles for bioactive compounds to the brain [61]

Glucuronides account for only 24% of total metabolites, with AUC ratios of 0.150.25 relative to HTX

They also collected blood samples from the participants to assess levels of 18 cardiovascular disease-related biomarkers

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