Hypoxia and inflammatory signals (such as LPS and succinate) can stabilize HIF-1, which in turn upregulates the expression of glycolytic enzymes and pro-inflammatory genes (such as IL-1) at the transcriptional level (45)
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131 A general rule of thumb that is usually performed is to thoroughly perform a transcriptomic analysis in order to detect differential gene expression at the wound site, followed by gene ontology correlation studies in order to map the main metabolic pathways of genes related wound healing
For the treatment of using that comprises nucleic acid, can prepare chemical compound of the present invention and comprise that to be used for multiple mode of administration general and part or local use.Technology is found in the Lei Mingdun pharmaceutical science usually with preparation, Meade Publishing Co., and Easton is among the Pa.For general is used, injection is preferred, comprises in intramuscular, intravenous, intraperitoneal, the knot and subcutaneous administration.In order to inject, can chemical compound of the present invention be formulated in liquid solution, the buffer of preferred physical compatibility is for example in Hank ' s liquid or the ringer's solution.In addition, can be with the solid form compositions formulated, it is dissolved again or suspend facing the time spent.Also comprise lyophilized form
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