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This process could lead to the production of biologically active immunomodulatory AA metabolites that could impact tumor immunotherapy [36]

Depletion of GSH due to intensified oxidative stress or the action of inhibitors significantly reduces the ability of GPX4 to counteract lipid peroxidation, leading to increased lipid peroxides and subsequent ferroptosis (151)

If you experience significant nausea during dose escalation, the standard approach is to hold at the current dose for an additional two to four weeks before attempting the next increase

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PMID 20200383

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