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2022 Dec 24;10(1):31

Inhibition or deficiency of cathepsin B leads defects in HIV-1 Gag pseudoparticle release in macrophages and HEK293T cells

Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, Nabet BY, Fujimoto J, Solis LM, Lu W, Xi Y, Cardnell RJ, Wang Q, Fabbri G, Cargill KR, Vokes NI, Ramkumar K, Zhang B, Della Corte CM, Robson P, Swisher SG, Roth JA , Glisson BS, Shames DS, Wistuba II, Wang J, Quaranta V, Minna J, Heymach JV, Byers LA

Fatty acid binding protein 4 (FABP4), a key mediator of macrophage lipid metabolism and inflammation, can promote the transformation of macrophages into myofibroblasts, facilitate lipid deposition, increase the content of free fatty acids, and accelerate RIF [99]

Additionally, trial NCT03608631 investigates the exosome-mediated delivery of KRAS G12D siRNA for pancreatic cancer, which, although not directly focused on respiratory diseases, highlights the broader therapeutic potential of nanocarriers in oncology (Narasipura et al., 2023)

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