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They observed increased reactive oxygen intermediates (ROIs), protein carbonyl contents (POPs), DNA oxidation products such as 8-hydroxy-2-deoxyguanosine (8-OHdG), and iron, and decreased copper and Cu-Zn SOD activity in CD biopsies

This review aims to outline the relevant mechanisms of ferroptosis, its implications in the bone microenvironment, and the mechanisms of action and therapeutic perspectives of ferroptosis in common bone and joint diseases, with the goal of informing future clinical research and treatment strategies targeting ferroptosis under these conditions

There were upregulated lipid peroxidation-related markers and inflammatory cytokines in both cellular and ex vivo models

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