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Recent meta-analyses have emphasized the need for larger-scale, rigorously designed randomized controlled trials to comprehensively determine FMT treatment efficacy and safety, while recommending that future research focus on establishing standardized analytical protocols and validating predictive biomarkers (Zhang et al., 2025)

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Histological studies showed amyloid plaques in the cortex and hippocampus beginning at 11 months, without evidence of NFTs