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The top three research priorities were found to be (1) understanding the biological mechanism behind PEM and how this can be treated or managed (2), which existing drugs used for other conditions would be useful in treating ME/CFS, and (3) finding accurate and reliable diagnostic testing for ME/CFS

5 Mitochondrial metabolism, inflammatory tone and insulin resistance As mentioned above, LAC is an endogenous compound essential for -oxidation and is an emerging epigenetic modulator of glutamatergic function