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129 DBS is gaining interest and showing clinical promise in patients with treatment-resistant major depression

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doi: 10.1074/jbc.274.2.795 70 ZhangJ

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Examining the expression of clock proteins at 4-hour intervals over a 24-hour period and their subcellular localisation during the light (10am) and the start of the dark period (6pm), revealed that BMAL1 expression was highest during the light period (6am-2pm) ( Figure 3A ), which corresponded with the nuclear localisation of BMAL1 at 10am ( Figure 5A )