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Elevated levels of BCAAs (leucine, isoleucine, and valine) have been consistently observed in patients with type 2 DM (T2DM), potentially linking to both immune dysregulation and insulin resistance (Wang et al., 2011)

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doi: 10.1038/s42255-019-0161-5

Delivery is considered the primary obstacle in gene therapy, and it is particularly crucial to the success of corneal gene therapy in ophthalmic diseases