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Methods: Adult Smo flox/flox mice were treated with control- or AAV8-TBG-Cre vectors to delete Smo specifically in hepatocytes, and fed with CDAA-HFD for 8 weeks to induce NAFLD

Nagai N

J Assoc Physicians India 72(9):32-36, 2024

Pancreatic stellate cell-derived alanine also acts as an alternative carbon source to fuel the tricarboxylic acid (TCA) cycle in pancreatic ductal adenocarcinoma cells [31]

For example, the folding of N-myristoylated G subunits of heterotrimeric G-proteins (~ 355 aa) requires the dedicated chaperone Ric-8A, which binds partially folded G, keeps the the N-myristate solvent-protected and only releases it upon client activation (via nucleotide binding) 47,48

Apoe / mice were irradiated lethally and reconstituted with BM from either Dj1 + / + Apoe / or Dj1 / Apoe / mice (referred herein as WT or KO BMT respectively)