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Efforts should be made to create pills containing only one type of microbe to enhance the immune response and improve patient treatment

doi: 10.1371/journal.pone.0073989.g001 140 ZhangY.KaiserE.MarcelisL

Efficacy of vafidemstat in experimental autoimmune encephalomyelitis highlights the KDM1A/RCOR1/HDAC epigenetic axis in multiple sclerosis

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Abbreviations 2-AG: 2-Arachidonoylglyerol 5HT 1A : 5-Hydroxytryptamine receptor 1A 5HT 3A : 5-Hydroxytryptamine receptor 3A 17OHP: Progesterone 17-hydroxylase ACOG: American College of Obstetrics and Gynecology ADORA 2A : Adenosine A 2A receptor AEA: Anandamide Caspase: 1-Cysteinyl aspartate protease 1 cAMP: Cyclic adenosine monophosphate CBD: Cannabidiol CBDV: Cannabidivarin CBC: Cannabichromene CBCV: Cannabichromevarin CBG: Cannabigerol CBDA: Cannabidioloic acid CBGA: Cannabigerolic acid CBGV: Cannabigerovarin CBN: Cannabinol CBNA: Cannabinolic acid CB 1 : Cannabinoid receptor type 1 CB 2 : Cannabinoid receptor type 2 CPS: Child Protective Services CYP: Cytochrome p450 enzyme CYP3A5: Cytochrome P450 3A5 CYP3A7: Cytochrome P450 3A7 CYP3A4: Cytochrome P450 3A4 CYP2C9: Cytochrome P450 2C9 CYP1A1: Cytochrome P450 1A1 CYP1A2: Cytochrome P450 1A2 CYP1B1: Cytochrome P450 1B1 CYP2D6: Cytochrome P450 2D6 CYP2C19: Cytochrome P450 2C19 CYP2B6: Cytochrome P450 2B6 CYP2J2: Cytochrome P450 2J2 D2: Dopamine receptors ERK1/2: Extracellular signal-regulated kinase FAAH: Fatty acid amine hydrolase FDA: Food and Drug Administration GPR55: G protein-coupled receptor 55

doi: 10.1016/j.fct.2018.02.022 34 KalantariHForuozandehHKhodayarMJSiahpooshASakiNKheradmandP