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Nuclear-magnetic-resonance study of the thioltransferase-catalyzed glutathione/glutathione disulfide interchange reaction

Sundaram ME, Meydani SN, Vandermause M, Shay DK, Coleman LA

ROS can lead to the disruption of hydrogen bonds and cause the unfolding and fragmentation of both double-stranded and single-stranded regions of the DNA double helix

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Thus, STW3-VI showed a protective effect against glutamate-induced oxidative stress by activation of the glutathione defense system (Figure 4A)

We then investigated whether BafA1 treatment would reveal lysosomal mislocalization of GNPT