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A principal transcription factor, NRF2, which stimulates the expression of a broad set of genes that act towards the restoration of redox balance and reduce the damage from ROS, in a large part regulates the response to oxidative stress (230, 231)

Oxidative stress, inflammation and accelerated ageing are accompanied by damage to the central nervous system, including neurodegeneration

Extrarenal mechanism include potassium uptake by both liver and muscle generally, and intestinal secretion of potassium

This triggers ferroptosis in terminally differentiated cardiomyocytes, ultimately leading to heart failure

IV therapy bypasses the digestive system to deliver nutrients straight into the bloodstream

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