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Mechanosensitive Piezo receptors (particularly the Piezo1 subtype) are found in the injury perception of the peripheral trigeminal nerve, and high-dose injections of Yoda1 can extend the meningeal arteries innervated by the trigeminal afferent nerve, leading to the development of migraines (Mikhailov et al., 2019)

However, even if this treatment may minimize the effect of potential interferents, it might also compromise the concentration of target biomarkers 78 as mucin which is an inflammatory biomarkers for periodontitis 79 and matrix metalloproteinases, 80 which can be lost from the sample upon membrane filtration procedures

Bottom line: The receptor desensitization story doesnt apply over the time periods that have been studied

PMC 3044191

Table 20 Necrosis scores 6 days post injections of subcutaneous tissue necrosis for co-formulation necrosis for co-formulation vehicles varying in percentage HP-B-CD Concluding Remarks A correlation was observed between increased HP-B-CD concentration in the coformulation vehicle and necrosis at the injection site

Conflicts of interest There are no conflicts of interest