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10.18632/aging.104022 23 ChenX.LiuY.ZhangQ.LiuB.ChengY.ZhangY.et al (2020b)

Focal TBI typically leads to primary axotomy along with ischemic and destructive neuronal changes, while diffuse TBI results in diffuse axonal injury, referred to as traumatic axonal injury (TAI) in the preclinical TBI model setting

Monitor for any paradoxical reactions

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However, this does not mean that all large amounts are necessarily harmless

yet, prolonged ROS exposure promotes 26S proteasome disassembly into 20S and 19S subunits [52], reducing ubiquitin-dependent degradation capacity [53]