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Conclusion: We demonstrate through multiple lines of evidence that the LPAR/PI3K/AKT axis is vital for the activation of YAP and hepatic fibrogenesis due to HIV infection

Unlike other cell death modalities, paraptosis lacks the typical apoptotic hallmarks, such as DNA condensation, DNA breakage, membrane blistering, and apoptotic bodies

J Thorac Cardiovasc Surg 154(2):568-569, 2017

Additionally, its higher levels were associated with metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), cancer, and pulmonary arterial hypertension (PAH), but with more controversy (80, 84)

For example, the epidermis is without a blood supply and does not have the same circulation and nutrient delivery found in the dermis [1,2,3]