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ECs are, thus, key players in the vasculature, sensing biomechanical and biochemical factors, which can induce rapid, short-term, and long-term adaptation processes [5,6,7,8,9]

A., Bjermer, L., Eriksson, L., Dahlstrom, K

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In hypercholesterolemic patients (n = 8, mean age 51.5) with slight luminal irregularities of the left anterior descending coronary artery (LAD), ACh-induced reduction in coronary blood flow, an indication of endothelial dysfunction, is improved by intracoronary injection of L-arginine (Drexler et al., 1991)