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Recent studies have reported that HSPCs develop trained immunity after stimulation with -glucan or BCG

Caspase-8dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

They believe tissue levels of those factors are probably far lower

doi: 10.1038/s41423-021-00726-4 110 MonaciSAldinucciCRossiDGiuntiniGFilippiIUlivieriCet al