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This is experimentally observed fact in the cultured corneal epithelial cells of human in which the expression of Tumor necrosis factor alpha (TNF-) was upregulated

It decreased the levels of inflammatory mediators associated with the MAPK and NF-B signaling pathways, suggesting its anti-inflammatory features

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A different study suggests that knockout mice deficient in caspase enzyme, tend to develop less severe tubular necrosis than their wild-type cousins 60