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however, sulfo-conjugation usually reduces biological activity

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In addition, the HMGB1-TLR2 signal can upregulate PD-L1 on neutrophils, inducing T cell apoptosis and causing immunosuppression, which may ultimately lead to multiple organ dysfunction (156)

On the other hand, evidence suggests that a short course of corticosteroids at the onset of the disease may be beneficial in patients with autoimmune hypophysitis after viral infections or vaccinations and may improve the associated immunological alterations (35, 74, 79, 242244)

CNPAGE CNPAGE was performed with modifications from a previously reported method 67

Additionally, the ghrelin receptor is abundantly expressed in somatotrophs of the pituitary gland, supporting the role of ghrelin in regulating GH release