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may cause orthostatic hypotension, gastroparesis, neurogenic bladder, sudomotor dysfunction

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Most commonly reported Mild stimulant-like effects (warmth, slight resting heart-rate rise) in the first 1 to 2 weeks

We reasoned that mouse models of 22q11.2DS might have metabolic disturbances similar to those reported in patients, in which case the in vivo genetic and pharmacological manipulation of the model should provide insights into the contribution of the metabolic phenotypes to the disease pathogenesis and/or disease mechanisms

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