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However, the phenomena that induce OS attributable to the patients aging, in addition to being variable in terms of intensity among individuals, are difficult to distinguish from those produced by the compromised antioxidant defense systems due to a neurodegenerative disease, such as ALS

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In the context of DCM, however, compromised lysosomal acidification and diminished hydrolase activity impede the degradation of autophagosomes, resulting in their progressive accumulation ( Various experimental models have demonstrated that in obesity and diabetes, cardiomyocytes show significant downregulation of lysosomal structural proteins and hydrolases