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For example, a compact structure may make the binding of GH receptors to GH in ice age animals more stable, which is beneficial for more effective utilization of growth hormone to regulate metabolic processes in low food resource environments

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The further roles of NNMT in regulating glucose metabolism and the related mechanisms are mainly from Kraus et al

The original Cell Metabolism discovery paper established that MOTS-c regulates insulin sensitivity through this pathway, and later work in Nature Communications by Reynolds et al

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Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites