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Estrogen plays a crucial role in the growth and development of breast tissue, whereas DEHP is able to emulate the natural estrogenic activities, thus interfering with the normal function of the endocrine system 25

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In the dermaroller with copper peptide group, female participants showed a notable decline, dropping from a baseline mean of 20 (SD = 5) to 12 (SD = 2) at the final visit, while male participants experienced a reduction from a baseline mean of 23 (SD = 6) to 18 (SD = 6) at the final visit