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Cons Some users reported mild skin reactions

Transgenic APPswe/PSEN1-dE9 mice spontaneously deposited more abnormal plaques than the wild-type ones, and the plaque reduction effect was not apparent when conducting sequential inhibitor administration

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V., Thoroughgood, C

However, gaps remain in the understanding of subset functions and regulatory mechanisms: in vitro studies rely on limited cell lines (e.g., HD11 macrophages, DF-1 fibroblasts), and the lack of long-term primary immune cell culture systems hinders simulation of in vivo cellular functions in complex microenvironments