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Description

These numbers exceeded the Phase 2 results, partly because the trial ran longer (68 weeks versus 48 weeks) and partly because the dose escalation schedule was refined

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68 In preclinical models, MOv18 IgE-induced cancer cell death by macrophage/monocyte dependent cytotoxic and phagocytic (ADCC and ADCP) mechanisms, as well as by promoting secretion of pro-inflammatory and macrophage chemotactic mediators such as tumor necrosis factor and monocyte chemoattractant protein-1

It is performed by a two-step process, in which amino acids are first activated by ATP, forming an intermediate aminoacyl adenylate, and then transferred to the 3-end of tRNA to form the end-product