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J Nutr 134:489492 Acknowledgements This work was supported by grants from the Spanish Ministry for Science and Innovation (BFU2008-04336 and SAF 2007-66878-C02-01), Research Group UCM (910379) and RETICEF (RD06/0013/0002 and RD06/0013/0003) from ISCIII

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Conceptually, there is a necessary shift away from traditional ecotoxicological tests focused on mechanistically opaque apical endpoints (e.g., mortality, LC50) towards frameworks that embrace causality