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After joint re-alignment, the muscle may stay activated, including maintaining muscle facia stretch, keeping the fascia tight, restricting the muscle from loosening, and causing pain from the proprioceptive and sensory nerve endings found in fascia

Since deletion of IL-1 reduces steatohepatitis, and fibrosis in mice fed a NASH-inducing diet (418), further investigation on the effects of canakinumab in human NASH are warranted

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