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12 mL/rat/day) or drinking water (12 mL/rat/day) (controls) until they were killed, at 1, 2, 3, 5, 7, 14, 21, 28, 60, and 90 post-operative days

Mazdutide A phase II, randomized, double-blind, placebo-controlled trial showed moderate weight loss with mazdutide in Chinese patients with overweight or obesity without T2DM)

In human clinical use, reported side effects are generally mild and transient: Mild injection site redness or discomfort (resolves within hours) Transient nausea in some patients, particularly early in the protocol Mild dizziness or light-headedness (rare, typically dose-related) Temporary fatigue in the first few days (often a sign of active tissue remodeling) No significant systemic toxicity, organ damage, hormonal suppression, or addiction potential has been documented in the published literature

CNS Drugs 2017;31:1057-82

The peptide remains accessible through certain research laboratories and compounding pharmacies, although this practice is subject to increasingly strict oversight