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A strong stream of cold air (a Zimmer cooler) is blown on the area during the treatment to make it comfortable

10.1016/j.jff.2021.104807 107 ZhouB.-G.LiuF.-C.ZhaoH.-M.ZhangX.-Y.WangH.-Y.LiuD.-Y

BMC Complement Med Ther 21:18 In, E

FIGURE 9 Discussion Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease characterized by a complex pathogenesis involving multiple interrelated processes, including intestinal barrier disruption, oxidative stress imbalance, excessive inflammatory activation, gut microbiota dysbiosis, and metabolic disturbances ( Body weight loss, colon shortening, and histological damage are hallmark pathological features of the DSS-induced UC model and serve as key metrics for evaluating therapeutic interventions

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Pentetrazole (PTZ) ignition is widely acknowledged as an animal model for studying epileptogenesis and evaluating antiepileptic drugs, as it lowers the threshold for epileptic seizures by repeatedly stimulating the brain chemically or electrically, ultimately resulting in seizures (Morimoto et al., 2004)