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Female FVB mice were purchased from Shanghai SLAC Laboratory Animal Company

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In particular, the pronounced straindependent differences observed among MSD21, MSD24, and MSD37 when grown on the same carbon source (including IR extract) across antioxidant, antiglycation, and prebiotic assays indicate that microbial metabolism and the resulting postbiotic metabolite profiles, rather than the substrate alone, are critical determinants of bioactivity

Omega-3 PUFAs activate transcription factors associated with the upregulation of antioxidant enzymes

However, the demonstration of increased homocysteine levels and the occurrence of anaemia and neuropathy [3] in metformin users suggests that biochemical vitamin B 12 deficiency may be clinically relevant [6]