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Nicotinamide N-methyltransferase (NNMT) is a key enzyme located in the cytosolic milieu that catalyzes the transfer of methyl group from the co-factor S-(5-Adenosyl)-L-methionine (SAM) to substrates such as nicotinamide (NCA), pyridine, and related analogs, such as quinoline, isoquinoline, and the1,2,3,4 tetrahydroisoquinoline.aliphatic amine NNMT directly regulates the detoxification of endogenous and exogenous drugs/xenobiotics by the formation of methylated metabolic products, such as 1-methyl nicotinamide (1-MNA), methylated pyridiniums, and methylated related analogs

Reta has improved my lipids, inflammation and my visceral/subcutaneous fat have also dropped.

More isnt always better when it comes to B12 injections

Sadly, its increasingly clear to me that the NHS (UK) has failed me with the time it took to achieve deficiency diagnosis (2+ years) and then infrequently poor / even refusal of treatment for a further 2 years

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However, even with a great diet, you may still miss out on two important nutrients: vitamin B12 and vitamin D