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The broader NNMT-as-therapeutic-target hypothesis is supported by knockdown and knockout studies, but small-molecule pharmacological validation in humans is pending

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For optimal B12 intake from meat sources, incorporating a variety of animal proteins, including occasional servings of organ meats (except during pregnancy), provides the most comprehensive nutritional approach

Other means are available for diagnosing the presence of B12 malabsorption caused by PA, the autoimmune disease that destroys the cells producing intrinsic factor