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196 Although the mutation frequency of E3 ubiquitin ligase is lower than that of other WNT inhibitors, mutations of RNF43 (which mediates ubiquitin degradation of Frizzled) are still detected in the adenoma tissues of patients with GC, 218 early-onset metastatic CRC, 219 and Lynch syndrome

Journal of Phycology , 41: 453-465

Furthermore, VPS39 was found to interact with ORF3a in two contemporaneous experimental SARS-CoV-2 virushost interactome studies 39,47 in addition to our results (Fig