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[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Miwa S., Kashyap S., Chini E., von Zglinicki T

Excessive ROS are key triggers of mitochondrial outer membrane permeabilization (MOMP) by activating and oligomerizing apoptogenic factors Bcl-2-associated X protein (BAX) and Bcl-2 homologous antagonist/killer (BAK) [7, 33, 34, 41], leading to the release of cytochrome c and the activation of caspases-9, 3 and 7 [42,43,44]

FIGURE 3 3.4 Luteolin inhibits integrin IIb3-mediated platelet activation Integrin IIb3-mediated platelet activation is the final common pathway for platelet activation induced by multiple activators (Figures 4A, B)

Furthermore, AI models trained on non-representative or biased datasets risk perpetuating existing health disparities and may exhibit poor generalizability across diverse populations

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